Anticipation is building ahead of the NFL's big Australian debut.

The San Francisco 49ers take on the Los Angeles Rams at the Melbourne Cricket Ground on Friday morning in what will be the league's first regular-season game in Australia, and just the second game overall of the 2026 season.

The match kicks off on Friday at 10.35am and is geared around the Thursday night TV audience in the US. Kick-off time will be 5.35pm on the US West Coast and 8.35pm on the East Coast.

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